Brock Purdy's Five Touchdowns Lead 49ers to Win Over Philip Rivers' Colts in Indianapolis
On December 22, 2025, Philip Rivers made his return to Indianapolis as the starting quarterback for the Colts in a game against the San Francisco 49ers held at Lucas Oil Stadium, with his family in attendance.
Rivers opened the game with a strong performance, leading the Colts on a 9-play, 72-yard drive capped by a 20-yard touchdown pass to Alec Pierce, putting the Colts up 7-0. In the first half, Rivers completed 14 of 21 passes for 175 yards and two touchdowns, including another 16-yard scoring pass to Pierce on a 12-play, 66-yard drive. This marked Rivers’ first multiple-touchdown regular-season game since December 20, 2020, versus the Texans.
Despite Rivers’ efforts, the halftime score was 49ers 24, Colts 17.
Brock Purdy led the San Francisco 49ers with an impressive performance, throwing five touchdown passes and completing 25 of 34 attempts for 295 yards. Purdy connected with several receivers, including a 3-yard touchdown catch by Jauan Jennings. Christian McCaffrey contributed 146 all-purpose yards with 117 rushing yards on 21 carries and was involved in multiple scoring plays. George Kittle added 115 yards on seven receptions but left early with an ankle injury. Defensive standout Dee Winters sealed the victory for San Francisco with a 74-yard interception return for a touchdown in the fourth quarter.
Rivers finished the game completing 23 of 35 passes for 277 yards, with two touchdowns and one interception. Alec Pierce totaled 86 yards on four receptions for the Colts, scoring both touchdowns in the first half.
The final score was 49ers 48, Colts 27. The loss dampened the Colts’ playoff hopes, as teams like the Jaguars, Bills, and Chargers had already clinched AFC playoff spots, while San Francisco solidified its position for the NFC No. 1 seed with two games remaining.
